Chronic Psychological Stress Was Not Ameliorated by Omega-3 Eicosapentaenoic Acid (EPA)

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Chronic Psychological Stress Was Not Ameliorated by Omega-3 Eicosapentaenoic Acid (EPA)

Background: Chronic psychological stress and mental health disorders are endemic in Western culture where population dietary insufficiencies of omega-3 fatty acids (n-3FA) from seafood have been observed. Objective: This study was designed to test for a causal relationship between one of the most active components of fish oil, eicosapentaenoic acid (EPA), and chronic psychological stress. Metho...

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Conversion of eicosapentaenoic acid to chain-shortened omega-3 fatty acid metabolites by peroxisomal oxidation.

Human skin fibroblasts can convert arachidonic acid to 14- and 16-carbon polyunsaturated fatty acid products by peroxisomal beta-oxidation. The purpose of this study was to determine whether similar products are formed from eicosapentaenoic acid (EPA) and whether EPA and arachidonic acid compete for utilization by this oxidative pathway. Three radiolabeled metabolites with shorter retention tim...

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Eicosapentaenoic acid (EPA) reduces cardiovascular events: relationship with the EPA/arachidonic acid ratio.

The clinical efficacy of fish oil and high-purity eicosapentaenoic acid ethyl ester (hp-EPA-E) for treating cardiovascular disease (CVD) has been reported. Fish oil contains saturated and monounsaturated fatty acids that have pharmacological effects opposite to those of ω3 fatty acids (ω3). Moreover, ω3, such as EPA and docosahexaenoic acid (DHA), do not necessarily have the same metabolic and ...

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EPA Omega-3 Supplementation in Early Psychosis

The evidence-based literature indicates, from isolated placebo-controlled studies in established schizophrenia and bipolar disorder, evidence that fish oil concentrates enriched in EPA may possibly offer some beneficial effects in psychotic disorders in selected patients. The present study was conducted to determine the potential efficacy of EPA omega-3 fatty acid supplementation in patients ex...

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Omega-3 Fatty Acids (epa & Dha)

Higher EPA & DHA Intake Lower Risk of Wet AMD in AREDS Researchers examined the relationship of AMD case groups in the AREDS trial and intake levels of dietary fats. Only higher intake of total EPA and DHA and fish were linked to a decreased likelihood of having neovascular AMD. Participants consuming the highest amount of arachidonic acid, an omega-6 fatty acid abundant in meat and dairy, were...

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ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2017

ISSN: 1663-9812

DOI: 10.3389/fphar.2017.00551